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    SOX18 Rabbit pAb (bs-17135R)  
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    產品編號 bs-17135R
    英文名稱 SOX18 Rabbit pAb
    中文名稱 轉錄因子SOX18抗體
    別    名 HLTS; SOX 18; Sox18; SOX18_HUMAN; SRY(sex determining region Y) box 18; SRY box 18; Transcription factor SOX 18; Transcription factor SOX-18.  
    研究領域 發育生物學  轉錄調節因子  表觀遺傳學  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    克 隆 號
    交叉反應 Mouse (predicted: Human,Rat,Pig,Cow,Dog,Rhesus monkey)
    產品應用 WB=1:500-2000
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    理論分子量 41 kDa
    檢測分子量
    細胞定位 細胞核 
    性    狀 Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human SOX18: 101-200/384 
    亞    型 IgG
    純化方法 affinity purified by Protein A
    緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    PubMed PubMed
    產品介紹 This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia. [provided by RefSeq, Jul 2008]

    Function:
    Binds to the consensus sequence 5'-AACAAAG-3' and is able to trans-activate transcription via this site.

    Subcellular Location:
    Nucleus.

    DISEASE:
    Defects in SOX18 are the cause of hypotrichosis-lymphedema-telangiectasia syndrome (HLTS) [MIM:607823].

    Similarity:
    Contains 1 HMG box DNA-binding domain.
    Contains 1 Sox C-terminal domain.

    SWISS:
    P35713

    Gene ID:
    54345

    Database links:

    Entrez Gene: 54345 Human

    Entrez Gene: 20672 Mouse

    Entrez Gene: 311723 Rat

    Omim: 601618 Human

    SwissProt: P35713 Human

    SwissProt: P43680 Mouse

    Unigene: 8619 Human

    Unigene: 264904 Mouse

    Unigene: 22446 Rat



    產品圖片
    Protein: heart(mouse)cell lysate at 40ug; Primary: rabbit Anti-SOX18 (bs-17135R) at 1:300; Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000; Predicted band size: 41 kD Observed band size: 41 kD
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