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    Mouse P4HB Ready-To-Use IHC Kit (IHC0488M)  
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    產品編號 IHC0488M
    英文名稱 Mouse P4HB Ready-To-Use IHC Kit
    中文名稱 小鼠蛋白質二硫鍵異構酶即用型免疫組化試劑盒
    別    名 CLCRP1; DSI; ERBA2L; ERp59; GIT; P4HB; P4Hbeta; PDI; PDIA1; PDIR; PHDB; PO4DB; PO4HB; PROHB; Thbp  
    克 隆 號
    適用樣品基質 FFPE tissue
    保存條件 Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt.
    產品介紹 Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, the protein seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. It may therefore cause structural modifications of exofacial proteins. Inside the cell, PDI seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, it functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, it facilitates aggregation (anti-chaperone activity). PDI may be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. It also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.

    SWISS:
    P07237

    Gene ID:
    5034

    產品圖片
    Immunohistochemical analysis of paraffin embedded mouse brain tissue slide using IHC0488M (Mouse P4HB IHC Kit).
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