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    Rabbit Anti-SLC33A1/APC Conjugated antibody (bs-0699R-APC)
    訂購熱線:400-901-9800
    訂購郵箱:sales@bioss.com.cn
    訂購QQ:  400-901-9800
    技術支持:techsupport@bioss.com.cn
    說 明 書: 100ul  
    100ul/2980.00元
    大包裝/詢價
    產品編號 bs-0699R-APC
    英文名稱 Rabbit Anti-SLC33A1/APC Conjugated antibody
    中文名稱 APC標記的乙酰輔酶A轉運蛋白1抗體
    別    名 AT-1; Solute carrier family 33, member 1; SLC33A1; ACATN; Acetyl CoA transporter; Acetyl Coenzyme A transporter; AT 1; AT1; Human Angiotensin II Type 1 Receptor; Solute carrier family 33 (acetyl CoA transporter) member 1; Solute carrier family 33 member 1; spastic paraplegia 42 (autosomal dominant); SPG42; ACATN_HUMAN; Acetyl coenzyme A transporter 1; Acetyl-CoA transporter 1; Acetyl-coenzyme A transporter 1; Slc33a1; Solute carrier family 33 (acetyl CoA transporter) member 1.  
    規格價格 100ul/2980元 購買        大包裝/詢價
    說 明 書 100ul  
    研究領域 細胞生物  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 (predicted: Human, Mouse, Rat, )
    產品應用 IF=1:50-200 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 61kDa
    性    狀 Lyophilized or Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human SLC33A1
    亞    型 IgG
    純化方法 affinity purified by Protein A
    儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    產品介紹 background:
    Acetyl-coenzyme A transportor 1 is required for the formation of O-acetylated (Ac) gangliosides. It is predicted to contain 6 to 10 transmembrane domains, and a leucine zipper motif in transmembrane domain III. Studies indicate that the protein is localized to the cytoplasm.

    Function:
    Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides.

    Subcellular Location:
    Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable).

    Tissue Specificity:
    Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. With strongest signals in pancreas.

    DISEASE:
    Defects in SLC33A1 are the cause of spastic paraplegia autosomal dominant type 42 (SPG42) [MIM:612539]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body

    Similarity:
    Belongs to the SLC33A transporter family.

    Database links:

    Entrez Gene: 9197 Human

    Entrez Gene: 64018 Rat

    Omim: 603690 Human

    SwissProt: O00400 Human

    SwissProt: Q6AYY8 Rat

    Unigene: 478031 Human

    Unigene: 209601 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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