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    Rabbit Anti-phospho-ZCWCC1 (Ser739)/Gold Conjugated antibody (bs-10016R-Gold)
    訂購熱線:400-901-9800
    訂購郵箱:sales@bioss.com.cn
    訂購QQ:  400-901-9800
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    說 明 書: 100ul(10nm  15nm  35nm
    100ul/2980.00元
    大包裝/詢價
    產品編號 bs-10016R-Gold
    英文名稱 Rabbit Anti-phospho-ZCWCC1 (Ser739)/Gold Conjugated antibody
    中文名稱 膠體金標記的磷酸化ZCWCC1抗體
    別    名 AC004542.C22.1.; p-MORC2(Ser739); phospho-ZCWCC1(Ser739); CW type with coiled coil domain 1; KIAA0852; ZCW3; ZCWCC1; Zinc finger; Zinc finger CW type coiled coil domain protein 1; Zinc finger CW type with coiled coil domain 1; Zing finger CW type 3 zinc finger CW-type coiled-coil domain protein 1; MORC family CW-type zine finger 2; MORC2.  
    規格價格 100ul/2980元 購買        大包裝/詢價
    說 明 書 100ul(10nm  15nm  35nm
    產品類型 磷酸化抗體 
    研究領域 細胞生物  轉錄調節因子  鋅指蛋白  表觀遺傳學  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 (predicted: Human, )
    產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 114kDa
    性    狀 Lyophilized or Liquid
    濃    度 0.4mg/ml
    免 疫 原 KLH conjugated synthesised phosphopeptide derived from human MORC2 around the phosphorylation site of Ser739
    亞    型 IgG
    純化方法 affinity purified by Protein A
    儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
    保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
    產品介紹 background:
    The CW domain is a structural module found in many vertebrate, parasitic and plant proteins. It consists of a mononuclear four-cysteine zinc-finger domain that plays a role in DNA binding, chromatin methylation and early embryonic development. ZCWCC1 (zinc finger CW-type coiled-coil domain protein 1), also known as MORC2 (MORC family CW-type zinc finger protein 2) or ZCW3, is a 1,032 amino acid protein that contains one CW-type zinc finger domain. ZCWCC1 is located on chromosome 22 and is ubiquitously expressed with highest expression in pancreas, smooth muscle and testis. Expression of ZCWCC1 is upregulated in hypoxia, a pathological condition characterized by an inadequate supply of oxygen in the blood.

    Function:
    May act as a transcriptional repressor. Down-regulates CA9 expression.

    Subunit:
    Interacts with HDAC4.

    Subcellular Location:
    Nucleus. Cytoplasm, cytosol. Note=Mainly located in the nucleus.

    Tissue Specificity:
    Highly expressed in smooth muscle, pancreas and testis.

    Similarity:
    Contains 1 CW-type zinc finger.

    Database links:
    UniProtKB/Swiss-Prot: Q9Y6X9.

    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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