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    Rabbit Anti-Smoothened/RBITC Conjugated antibody (bs-2801R-RBITC)
    訂購熱線:400-901-9800
    訂購郵箱:sales@bioss.com.cn
    訂購QQ:  400-901-9800
    技術支持:techsupport@bioss.com.cn
    說 明 書: 100ul  
    100ul/2980.00元
    大包裝/詢價
    產品編號 bs-2801R-RBITC
    英文名稱 Rabbit Anti-Smoothened/RBITC Conjugated antibody
    中文名稱 羅丹明(RBITC)標記的跨膜蛋白Smoothened抗體
    別    名 Gx; Gx protein; SMO; SMOH; Smoothened homolog (Drosophila); Smoothened homolog; Smoothened homolog precursor (SMO) (Gx protein); SMO_HUMAN.  
    規格價格 100ul/2980元 購買        大包裝/詢價
    說 明 書 100ul  
    研究領域 腫瘤  免疫學  信號轉導  細胞膜受體  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
    產品應用
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 84kDa
    性    狀 Lyophilized or Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human Smoothened
    亞    型 IgG
    純化方法 affinity purified by Protein A
    儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    產品介紹 background:
    The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]

    Function:
    G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.

    Subunit:
    Interacts with ARRB2. Interacts with KIF7.

    Subcellular Location:
    Membrane.

    Similarity:
    Belongs to the G-protein coupled receptor Fz/Smo family.
    Contains 1 FZ (frizzled) domain.

    Database links:

    Entrez Gene: 395949 Chicken

    Entrez Gene: 100033990 Horse

    Entrez Gene: 6608 Human

    Entrez Gene: 319757 Mouse

    Entrez Gene: 25273 Rat

    Entrez Gene: 30225 Zebrafish

    Omim: 601500 Human

    SwissProt: O42224 Chicken

    SwissProt: Q99835 Human

    SwissProt: P56726 Mouse

    SwissProt: P97698 Rat

    Unigene: 437846 Human

    Unigene: 29279 Mouse

    Unigene: 44429 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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