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    Rabbit Anti-ICAD/HRP Conjugated antibody (bs-0214R-HRP)
    訂購熱線:400-901-9800
    訂購郵箱:sales@bioss.com.cn
    訂購QQ:  400-901-9800
    技術支持:techsupport@bioss.com.cn
    說 明 書: 100ul  
    100ul/2980.00元
    大包裝/詢價
    產品編號 bs-0214R-HRP
    英文名稱 Rabbit Anti-ICAD/HRP Conjugated antibody
    中文名稱 辣根過氧化物酶標記的Caspase激活的脫氧核糖核酸酶抑制劑抗體
    別    名 DFF-45 Beta; ICAD; ICAD L; ICAD S; Caspase activated deoxyribonuclease inhibitor short form; DFF 1; DFF 45; DFF-45; DFF alpha; DFF1; DFF35; DFF45; DFFA; Dffa DNA fragmentation factor, alpha subunit; DNA fragmentation factor 45 kDa subunit; DNA Fragmentation Factor Alpha Subunit; DNA fragmentation factor subunit alpha; DNA fragmentation factor, 45 kD, alpha subunit; DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA), transcript variant 1; A330085O09Rik; DNA fragmentation factor, 45kDa, alpha polypeptide; DNA fragmentation factor, alpha subunit; H13; Inhibitor of CAD; DFFA_HUMAN; Inhibitor of CAD; Inhibitor of Caspase Activated DNase; MGC143066; OTTHUMP00000001903; OTTHUMP00000001904; RP23 121D17.3;Inhibitor of Caspase Activated DNase.  
    規格價格 100ul/2980元 購買        大包裝/詢價
    說 明 書 100ul  
    研究領域 細胞生物  免疫學  染色質和核信號  細胞凋亡  新陳代謝  表觀遺傳學  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 Human, Mouse, Rat, 
    產品應用 WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 36kDa
    性    狀 Lyophilized or Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human ICAD
    亞    型 IgG
    純化方法 affinity purified by Protein A
    儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    產品介紹 background:
    Caspase-activated deoxyribonuclease(CAD) also designated DNA fragmentation factor 45 kDa subunit (DFF-45)and Caspase-activated DNase. CAD is a nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. ICAD (DNA fragmentation factor alpha subunit) (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) is inhibitor of the caspase-activated DNase (DFF44).

    Function:
    Inhibitor of the caspase-activated DNase (DFF40).

    Subunit:
    Heterodimer of DFFA and DFFB.

    Subcellular Location:
    Cytoplasm.

    Post-translational modifications:
    Caspase-3 cleaves DFF45 at 2 sites to generate an active factor.

    Similarity:
    Contains 1 CIDE-N domain.

    Database links:

    Entrez Gene: 1676 Human

    Omim: 601882 Human

    SwissProt: O00273 Human

    Unigene: 484782 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    ICAD 是在細胞凋亡期誘導DNA分裂和染色體固縮的一種核酶,降解裸露的DNA 并誘導形態學變化。
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