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    Rabbit Anti-REC8/BF647 Conjugated antibody (bs-7723R-BF647)
    訂購熱線:400-901-9800
    訂購郵箱:sales@bioss.com.cn
    訂購QQ:  400-901-9800
    技術支持:techsupport@bioss.com.cn
    說 明 書: 100ul  
    100ul/2980.00元
    大包裝/詢價
    產品編號 bs-7723R-BF647
    英文名稱 Rabbit Anti-REC8/BF647 Conjugated antibody
    中文名稱 BF647標記的減數分裂重組蛋白家族REC8抗體
    別    名 Cohesin Rec8p; Meiotic recombination protein REC8 homolog; Meiotic recombination protein REC8-like 1; rec8; REC8 homolog (yeast); REC8_HUMAN; REC8L; Rec8L1; Rec8p.  
    規格價格 100ul/2980元 購買        大包裝/詢價
    說 明 書 100ul  
    研究領域 細胞生物  細胞周期蛋白  細胞分化  表觀遺傳學  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 Human, Rat,  (predicted: Mouse, Dog, Pig, Horse, Rabbit, Guinea Pig, )
    產品應用 Flow-Cyt=1:50-200 IF=1:50-200 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 60kDa
    性    狀 Lyophilized or Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human REC8
    亞    型 IgG
    純化方法 affinity purified by Protein A
    儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    產品介紹 background:
    Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.

    Function:
    Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity).

    Subunit:
    Interacts (phosphorylated and unphosphorylated form) with SMC3. Interacts with SYCP3. Interacts (phosphorylated and unphosphorylated form) with SMC1B. Does not interact with SMC1A. Interacts with RAD51.

    Subcellular Location:
    Nucleus. Chromosome.

    Tissue Specificity:
    Expressed in testis and thymus.

    Similarity:
    Belongs to the rad21 family.

    Database links:

    Entrez Gene: 9985 Human

    Entrez Gene: 56739 Mouse

    Entrez Gene: 290227 Rat

    Omim: 608193 Human

    SwissProt: O95072 Human

    SwissProt: Q8C5S7 Mouse

    SwissProt: Q6AYJ4 Rat

    Unigene: 419259 Human

    Unigene: 23149 Mouse

    Unigene: 108612 Rat




    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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