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    Rabbit Anti-FNIP1/AP Conjugated antibody (bs-13193R-AP)
    訂購熱線:400-901-9800
    訂購郵箱:sales@bioss.com.cn
    訂購QQ:  400-901-9800
    技術支持:techsupport@bioss.com.cn
    說 明 書: 100ul  
    100ul/2980.00元
    大包裝/詢價
    產品編號 bs-13193R-AP
    英文名稱 Rabbit Anti-FNIP1/AP Conjugated antibody
    中文名稱 堿性磷酸酶(AP)標記的卵泡刺激素結合蛋白1抗體
    別    名 KIAA1961; FLCN-interacting protein; FNIP1; Folliculin interacting protein 1; FNIP1_HUMAN.  
    規格價格 100ul/2980元 購買        大包裝/詢價
    說 明 書 100ul  
    研究領域 細胞生物  發育生物學  結合蛋白  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Horse, Sheep, )
    產品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 130kDa
    性    狀 Lyophilized or Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human FNIP1
    亞    型 IgG
    純化方法 affinity purified by Protein A
    儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    產品介紹 background:
    May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.

    Function:
    May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.

    Subunit:
    Forms homomultimers and heteromultimers with FNIP2. Interacts with FLCN (via C-terminus), with HSPCA and with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase (AMPK). Phosphorylated FLCN and AMPK are preferentially bound.

    Subcellular Location:
    Cytoplasm.

    Tissue Specificity:
    Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney tissue.

    Post-translational modifications:
    Phosphorylated by AMPK.

    Similarity:
    Belongs to the FNIP family.

    Database links:

    Entrez Gene: 96459 Human

    Omim: 610594 Human

    SwissProt: Q8TF40 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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