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    Rabbit Anti-phospho-IL10RA (Ser319 + Ser323) /RBITC Conjugated antibody (bs-18131R-RBITC)
    訂購熱線:400-901-9800
    訂購郵箱:sales@bioss.com.cn
    訂購QQ:  400-901-9800
    技術支持:techsupport@bioss.com.cn
    說 明 書: 100ul  
    100ul/2980.00元
    大包裝/詢價
    產品編號 bs-18131R-RBITC
    英文名稱 Rabbit Anti-phospho-IL10RA (Ser319 + Ser323) /RBITC Conjugated antibody
    中文名稱 羅丹明(RBITC)標記的磷酸化白細胞介素-10受體a抗體
    別    名 IL10RA (phospho S319 + S323); p-IL10RA (phospho S319 + S323); CD210; CDw210a; CDw210a antigen; HIL 10R; HIL10R; I10R1_HUMAN; IL 10R 1; IL 10R A; IL 10R; IL 10R1; IL-10 receptor subunit alpha; IL-10R subunit 1; IL-10R subunit alpha; IL-10R1; IL-10RA; IL10R; IL10R1; IL10RA; Interleukin 10 receptor alpha; Interleukin 10 receptor alpha chain; Interleukin-10 receptor subunit 1; Interleukin-10 receptor subunit alpha.  
    規格價格 100ul/2980元 購買        大包裝/詢價
    說 明 書 100ul  
    產品類型 磷酸化抗體 
    研究領域 細胞生物  免疫學  信號轉導  細胞膜蛋白  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 (predicted: Human, )
    產品應用 ICC=1:50-200 IF=1:50-200 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 63kDa
    性    狀 Lyophilized or Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human phospho-IL10RA (Ser319 + Ser323)
    亞    型 IgG
    純化方法 affinity purified by Protein A
    儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    產品介紹 background:
    The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]

    Function:
    Receptor for IL10; binds IL10 with a high affinity.

    Subcellular Location:
    Membrane.

    Tissue Specificity:
    Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels.

    DISEASE:
    Inflammatory bowel disease 28

    Similarity:
    Belongs to the type II cytokine receptor family.

    Database links:

    Entrez Gene: 3587 Human

    Omim: 146933 Human

    SwissProt: Q13651 Human

    Unigene: 504035 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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