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    Rabbit Anti-SLC4A5/HRP Conjugated antibody (bs-21017R-HRP)
    訂購熱線:400-901-9800
    訂購郵箱:sales@bioss.com.cn
    訂購QQ:  400-901-9800
    技術支持:techsupport@bioss.com.cn
    說 明 書: 100ul  
    100ul/2980.00元
    大包裝/詢價
    產品編號 bs-21017R-HRP
    英文名稱 Rabbit Anti-SLC4A5/HRP Conjugated antibody
    中文名稱 辣根過氧化物酶標記的碳酸氫鈉協同轉運蛋白4-A5抗體
    別    名 NBC4; Electrogenic sodium bicarbonate cotransporter 4; MGC129662; NBC4; NBCe2; S4A5_HUMAN; SLC4A5; Solute carrier family 4 member 5; Solute carrier family 4 sodium bicarbonate cotransporter member 5.  
    規格價格 100ul/2980元 購買        大包裝/詢價
    說 明 書 100ul  
    研究領域 腫瘤  細胞生物  神經生物學  信號轉導  轉運蛋白  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, )
    產品應用 WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 126kDa
    性    狀 Lyophilized or Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human SLC4A5
    亞    型 IgG
    純化方法 affinity purified by Protein A
    儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    產品介紹 background:
    This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

    Function:
    Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH.

    Subcellular Location:
    Apical cell membrane. Expressed in the apical plasma membrane domain of a subset of collecting ducts in the renal medulla.

    Tissue Specificity:
    Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach and small intestine. Weakest expression seen in peripheral blood lymphocytes, colon, duodenum, jejunum, ileum and skeletal muscle.

    Similarity:
    Belongs to the anion exchanger (TC 2.A.31) family.

    Database links:

    Entrez Gene: 57835 Human

    Entrez Gene: 232156 Mouse

    Entrez Gene: 297386 Rat

    Omim: 606757 Human

    SwissProt: Q9BY07 Human

    SwissProt: D3YX36 Mouse

    SwissProt: Q6RI88 Rat

    Unigene: 728220 Human

    Unigene: 214577 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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