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    Rabbit Anti-Plakophilin 4/Cy3 Conjugated antibody (bs-12711R-Cy3)
    訂購熱線:400-901-9800
    訂購郵箱:sales@bioss.com.cn
    訂購QQ:  400-901-9800
    技術支持:techsupport@bioss.com.cn
    說 明 書: 100ul  
    100ul/2980.00元
    大包裝/詢價
    產品編號 bs-12711R-Cy3
    英文名稱 Rabbit Anti-Plakophilin 4/Cy3 Conjugated antibody
    中文名稱 Cy3標記的橋粒斑菲素蛋白4抗體
    別    名 Catenin 4 ; Catenin4 ; FLJ31261 ; FLJ42243 ; p0071 ; PKP 4 ; PKP4 ; PKP4_HUMAN ; Plakophilin-4 ; Plakophilin4.  
    規格價格 100ul/2980元 購買        大包裝/詢價
    說 明 書 100ul  
    研究領域 細胞生物  發育生物學  信號轉導  
    抗體來源 Rabbit
    克隆類型 Polyclonal
    交叉反應 Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
    產品應用 ICC=1:50-200 IF=1:50-200 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 132kDa
    性    狀 Lyophilized or Liquid
    濃    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human Plakophilin 4
    亞    型 IgG
    純化方法 affinity purified by Protein A
    儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    產品介紹 background:
    Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]

    Function:
    May play a role in junctional plaques.

    Subcellular Location:
    Cell junction > desmosome. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells.

    Post-translational modifications:
    Phosphorylated upon DNA damage, probably by ATM or ATR.

    Similarity:
    Belongs to the beta-catenin family.
    Contains 9 ARM repeats.

    Database links:

    Entrez Gene: 281406 Cow

    Entrez Gene: 8502 Human

    Entrez Gene: 227937 Mouse

    Entrez Gene: 295625 Rat

    Omim: 604276 Human

    SwissProt: Q99569 Human

    SwissProt: Q68FH0 Mouse

    Unigene: 407580 Human

    Unigene: 260938 Mouse



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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